Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816670 | 1.00 | DRD2 (0.48) | DRD2DRD3TMEM97SIGMAR1HTR1D | |
| SCHEMBL7030108 | 1.00 | DRD2 (0.48) | DRD2DRD3TMEM97SIGMAR1HTR1D | |
| SCHEMBL7030804 | 0.91 | DRD2 (0.56) | DRD2DRD3 | |
| SCHEMBL7025402 | 0.91 | DRD2 (0.56) | DRD2DRD3 | |
| SCHEMBL7020675 | 0.90 | DRD2 (0.52) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7243293 | 0.88 | HTR1A (0.47) | DRD2DRD3SIGMAR1HTR1DHTR1B | |
| SCHEMBL7029876 | 0.88 | DRD2 (0.50) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7026968 | 0.87 | DRD2 (0.49) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL6820232 | 0.87 | HTR1D (0.45) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7028661 | 0.86 | DRD2 (0.48) | DRD2DRD3HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159971-A | Combination of a 5-HT reuptake inhibitor and a h5-HT1B anatagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | disclosed |
| EP-1014985-A1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A h5-HT 1B ANTAGONIST OR PARTIAL AGONIST | AstraZeneca AB (SE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999013877-A1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 1999-03-25 | — | — | WO | disclosed |