Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.39 |
| ▸ | CA1 | P00915 | 7/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27406766 | 0.80 | CA2 (0.41) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL23648019 | 0.79 | CA2 (0.36) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL27912418 | 0.78 | CA2 (0.44) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9578557 | 0.76 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9578565 | 0.76 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL27096242 | 0.76 | CA2 (0.43) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL28345876 | 0.76 | CA2 (0.43) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL188294 | 0.75 | CA1 (0.30) | CA2CA1 | |
| SCHEMBL28458609 | 0.74 | CA2 (0.41) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL167861 | 0.72 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599922-B2 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE) | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.P.A. (IT) | 2003-07-29 | — | — | US | disclosed |
| US-6599922-B2 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE) | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.P.A. (IT) | 2003-07-29 | — | — | US | disclosed |
| US-20030032835-A1 | Antiarrhythmia agents | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.P.A (IT) | 2003-02-13 | — | — | US | disclosed |
| US-20030032835-A1 | Antiarrhythmia agents | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.P.A (IT) | 2003-02-13 | — | — | US | disclosed |
| EP-1283201-A1 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamide (flecanide) | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. (IT) | 2003-02-12 | — | — | EP | disclosed |
| EP-1283201-A1 | Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamide (flecanide) | A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A. (IT) | 2003-02-12 | — | — | EP | disclosed |