Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 3/20 | 0.33 |
| ▸ | MC5R | P33032 | 3/20 | 0.33 |
| ▸ | MC3R | P41968 | 3/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 3/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.32 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032492 | 0.89 | MMP2 (0.34) | MMP2GSRMC4RMC5RMC3R | |
| SCHEMBL7030791 | 0.87 | ANPEP (0.40) | MMP2ANPEPRNPEPDNPEPNOS3 | |
| SCHEMBL7027416 | 0.86 | FNTA (0.33) | ANPEPRNPEPDNPEPNOS3NOS1 | |
| SCHEMBL7029892 | 0.86 | MMP2 (0.37) | MMP2THRBGSRMC4RMC5R | |
| SCHEMBL7028776 | 0.79 | ANPEP (0.34) | ANPEPRNPEPDNPEPNOS3NOS1 | |
| SCHEMBL7029135 | 0.74 | MMP2 (0.36) | MMP2GSRMC4RMC5RMC3R | |
| SCHEMBL7031217 | 0.72 | MARS1 (0.36) | — | |
| SCHEMBL7028027 | 0.72 | ANPEP (0.43) | ANPEPRNPEPDNPEPNOS3NOS1 | |
| SCHEMBL30191467 | 0.71 | MC4R (0.48) | MMP2MC4RMC5RMC3RANPEP | |
| SCHEMBL27920888 | 0.71 | MC4R (0.52) | MMP2GSRMC4RMC5RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |