Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30403463 | 0.89 | ITGB2 (0.43) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL3520940 | 0.81 | ITGB2 (0.43) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL10599290 | 0.79 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL30403909 | 0.79 | ITGB2 (0.40) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL30403679 | 0.77 | MAP3K14 (0.37) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL19852058 | 0.77 | AKR1B1 (0.37) | ITGB2ICAM1ITGAL | |
| SCHEMBL23704876 | 0.77 | BACE1 (0.41) | LMNAHTTKMT2AGAA | |
| SCHEMBL2632863 | 0.73 | ITGB2 (0.46) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL24162776 | 0.72 | ITGB2 (0.44) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL14031240 | 0.71 | TAAR1 (0.34) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596758-B1 | Treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds. | MERCK PATENT GMBH (DE) | 2003-07-22 | — | — | US | disclosed |
| EP-1140893-B1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-05 | — | — | EP | disclosed |
| EP-1140893-A1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039113-A1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2000-07-06 | — | — | WO | disclosed |