Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036689 | 0.93 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7033522 | 0.88 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14TDP1 | |
| SCHEMBL7036626 | 0.88 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7033586 | 0.83 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7030728 | 0.81 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7037902 | 0.81 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7033611 | 0.81 | MAPK13 (0.48) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7030739 | 0.81 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL7039968 | 0.80 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7037776 | 0.80 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | disclosed |