Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032174 | 0.93 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL7033586 | 0.92 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14TYK2 | |
| SCHEMBL7036626 | 0.84 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7033522 | 0.82 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL7040291 | 0.81 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL7040242 | 0.80 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL7030739 | 0.79 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL7037776 | 0.79 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL7039968 | 0.77 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL7032500 | 0.76 | KDR (0.48) | MAPK13MAPK12MAPK11MAPK14RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | claimed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | claimed |