Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799143 | 1.00 | ENPP2 (0.52) | ENPP2SIGMAR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5981283 | 1.00 | ENPP2 (0.52) | ENPP2SIGMAR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7382258 | 0.93 | ALDH1A1 (0.46) | ENPP2SIGMAR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5123960 | 0.93 | ALDH1A1 (0.52) | ENPP2SIGMAR1ALDH1A1TSHRCCR5 | |
| SCHEMBL27652104 | 0.93 | ALDH1A1 (0.52) | ENPP2SIGMAR1ALDH1A1TSHRCCR5 | |
| SCHEMBL5122891 | 0.93 | ALDH1A1 (0.52) | ENPP2SIGMAR1ALDH1A1TSHRCCR5 | |
| SCHEMBL7275332 | 0.91 | ENPP2 (0.49) | ENPP2SIGMAR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7275912 | 0.86 | ENPP2 (0.42) | ENPP2SIGMAR1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL15649454 | 0.86 | ENPP2 (0.44) | ENPP2SIGMAR1ALDH1A1TSHRTRPM8 | |
| SCHEMBL15648931 | 0.86 | ENPP2 (0.47) | ENPP2SIGMAR1ALDH1A1TSHRTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929571-B1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2003-02-26 | — | — | EP | disclosed |
| EP-0929571-A1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (CA) | 1999-07-21 | — | — | EP | disclosed |
| US-5916887-A | TREATMENT OF ARTHRITIS, INFLAMMATION, ALZHEIMER'S DISEASE | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 1999-06-29 | — | — | US | disclosed |
| WO-1998012210-A1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (US) | 1998-03-26 | — | — | WO | disclosed |