Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 6/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033260 | 1.00 | PPARG (0.52) | PPARGPPARACACNA1BJAK3BTK | |
| SCHEMBL20028772 | 0.92 | ABCB1 (0.52) | PPARGPPARACACNA1BJAK3BTK | |
| SCHEMBL15275069 | 0.91 | JAK3 (0.49) | PPARGPPARACACNA1BJAK3BTK | |
| SCHEMBL9963893 | 0.89 | CTSS (0.60) | PPARAJAK3BTKITGB3ITGA2B | |
| SCHEMBL740864 | 0.88 | CTSS (0.60) | CACNA1BJAK3BTKITGB3ITGA2B | |
| SCHEMBL6345086 | 0.88 | JAK3 (0.51) | PPARGPPARACACNA1BJAK3BTK | |
| SCHEMBL3989315 | 0.88 | CTSS (0.60) | JAK3BTKITGB3ITGA2BHDAC8 | |
| SCHEMBL13977456 | 0.88 | CTSS (0.60) | CACNA1BJAK3BTKITGB3ITGA2B | |
| SCHEMBL740863 | 0.88 | CTSS (0.60) | CACNA1BJAK3BTKITGB3ITGA2B | |
| SCHEMBL268923 | 0.88 | JAK3 (0.51) | PPARGPPARACACNA1BJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002048097-A9 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS | CORVAS INT INC (US) | 2003-05-08 | — | — | WO | disclosed |
| US-20020107266-A1 | Compounds, compositions and methods for treatment of parasitic infections | DENDREON CORPORATION | 2002-08-08 | — | — | US | disclosed |
| WO-2002048097-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS | CORVAS INTERNATIONAL, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
| EP-0528891-B1 | METHOD FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY | ALKERMES INC (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-0585412-B1 | INCREASING BLOOD-BRAIN BARRIER PERMEABILITY WITH PERMEABILIZER PEPTIDES | ALKERMES INC (US) | 1999-07-07 | — | — | EP | disclosed |
| EP-0885900-A2 | Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin | ALKERMES, INC. (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5686416-A | BRADYKININ ANALOGUES; NONA-, DECA- AND POLYPEPTIDES | ALKERMES, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506206-A | ARGININE-PROLINE-HYDROXYPROLINE-GLYCINE-THIENYLALANINE-SERINE -(4-METHYL-TYROSINE)-ARGANINE OR A CONFORMATIONAL ANALOGUE, USED AS THERAPEUTICAL OR DIAGNOSTIC AGENTS | ALKERMES, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0585412-A1 | INCREASING BLOOD-BRAIN BARRIER PERMEABILITY WITH PERMEABILIZER PEPTIDES | ALKERMES, INC. (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5268164-A | Intravascular administering a oligopeptide | ALKERMES, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0528891-A1 | METHOD FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY | ALKERMES, INC. (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1992018529-A1 | INCREASING BLOOD-BRAIN BARRIER PERMEABILITY WITH PERMEABILIZER PEPTIDES | ALKERMES, INC. (US) | 1992-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107266-A1 | Compounds, compositions and methods for treatment of parasitic infections | CAT, CTSA, CTRL | PPARG 1973/4885PPARA 2020/4885CACNA1B 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.