Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.73 |
| ▸ | MAOB | P27338 | 3/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12182938 | 0.92 | MAOB (0.63) | PTPN1MAOBNR4A2SMPD1NR1H4 | |
| SCHEMBL31130421 | 0.89 | PTPN1 (0.78) | PTPN1MAOBNR4A2SMPD1SRD5A2 | |
| SCHEMBL1819500 | 0.88 | PTPN1 (0.68) | PTPN1MAOBNR4A2SMPD1SRD5A2 | |
| SCHEMBL31130133 | 0.87 | SMN1; SMN2 (0.53) | PTPN1ALDH1A1MEN1KMT2ANR1H4 | |
| SCHEMBL12182447 | 0.87 | PTPN1 (0.55) | PTPN1MAOBNR4A2SMPD1NR1H4 | |
| SCHEMBL70341 | 0.86 | ALDH1A1 (0.63) | PTPN1MAOBNR4A2SRD5A2ALDH1A1 | |
| SCHEMBL17978704 | 0.85 | MAOB (0.66) | PTPN1MAOBNR4A2SMPD1SRD5A2 | |
| SCHEMBL6951340 | 0.84 | PTPN1 (1.00) | PTPN1MAOBNR4A2SMPD1SRD5A2 | |
| SCHEMBL4950266 | 0.82 | MAOB (0.63) | PTPN1MAOBNR4A2SMPD1SRD5A2 | |
| SCHEMBL12182346 | 0.82 | SMN1; SMN2 (0.51) | PTPN1ALDH1A1MEN1KMT2AERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129376-B2 | Piperidine derivatives as inhibitors of stearoyl-CoA desaturase | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-03-06 | — | — | US | disclosed |
| EP-2268143-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | Forest Laboratories Holdings Limited (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239810-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | PTPN1 4658/4885MAOB 1648/4885NR4A2 2165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.