Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | CA12 | O43570 | 3/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA7 | P43166 | 3/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783695 | 0.82 | ALDH1A1 (0.42) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL13016682 | 0.80 | ALDH1A1 (0.57) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL6628820 | 0.76 | ALDH1A1 (0.57) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL8926859 | 0.75 | ALDH1A1 (0.59) | ALDH1A1CA12CA1CA7CA9 | |
| 114, 10,10-Dimethyl-11-Demethyl-12-Oxo Calanolide A SCHEMBL13016680 | 0.74 | ALDH1A1 (0.58) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL8467499 | 0.74 | ALDH1A1 (0.63) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL6652226 | 0.74 | ALDH1A1 (0.60) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL6628817 | 0.74 | ALDH1A1 (0.58) | ALDH1A1CA12CA1CA7CA9 | |
| SCHEMBL13016937 | 0.74 | ALDH1A1 (0.58) | ALDH1A1CA12CA1CA7CA9 | |
| Calanolide A SCHEMBL140017 | 0.74 | ALDH1A1 (1.00) | ALDH1A1CA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020013478-A1 | Calanolide analogues and methods of their use | SARAWAK MEDICHEM PHARMACEUTICALS,INC. | 2002-01-31 | — | — | US | claimed |
| US-6277879-B1 | VIRICIDES | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2001-08-21 | — | — | US | claimed |
| EP-1308448-A1 | Method for the preparation of chromanone | Sarawak Medichem Pharmaceuticals Inc. (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0775130-B1 | METHOD FOR THE PREPARATION OF (+/-)-CALANOLIDE A AND INTERMEDIATES THEREOF | SARAWAK MEDICHEM PHARMACEUTICALS INC (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1143952-B1 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUBERCULOSIS | SARAWAK MEDICHEM PHARMACEUTICALS INC (US) | 2003-02-26 | — | — | EP | disclosed |
| US-20020013478-A1 | Calanolide analogues and methods of their use | SARAWAK MEDICHEM PHARMACEUTICALS,INC. | 2002-01-31 | — | — | US | disclosed |
| US-6268393-B1 | CALANOLIDES AND ANALOGUES THEREOF | SARAWAK MEDICHEM PHARMACEUTICALS | 2001-07-31 | — | — | US | disclosed |
| EP-1054007-A2 | Method for the preparation of (+/-)-calanolide A | MEDICHEM RESEARCH, INC. (US) | 2000-11-22 | — | — | EP | disclosed |
| US-6043271-A | Method for the preparation of (±)-calanolide A and intermediates thereof | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5981770-A | HIV REVERSE TRANSCRIPTASE INHIBITOR, VIRICIDE | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1996004263-A1 | METHOD FOR THE PREPARATION OF (±)-CALANOLIDE A AND INTERMEDIATES THEREOF | MEDICHEM RESEARCH, INC. (US) | 1996-02-15 | — | — | WO | disclosed |
| US-5489697-A | Method for the preparation of (+)-calanolide A and intermediates thereof | MEDICHEM RESEARCH, INC. (US) | 1996-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013478-A1 | Calanolide analogues and methods of their use | HAVCR2, ZC3HAV1, CYP51A1 | ALDH1A1 3786/4885CA12 957/4885CA1 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.