Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | RAB7A | P51149 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029267 | 0.83 | KMT2A (0.33) | RAB7APTPN1KMT2ANOD1POLB | |
| SCHEMBL6432093 | 0.80 | PTPN2 (0.34) | PTPN1POLB | |
| SCHEMBL6414118 | 0.78 | PTPN1 (0.48) | ABCC1ABCG2CXCR2PTPN1 | |
| SCHEMBL6432360 | 0.76 | KMT2A (0.32) | RAB7APTPN1KMT2ANOD1POLB | |
| SCHEMBL7855098 | 0.74 | PTPN2 (0.58) | PTPN1KMT2ANOD1POLBCASP6 | |
| SCHEMBL7693899 | 0.73 | PTPN1 (0.53) | ABCC1PTPN1KMT2ANOD1POLB | |
| SCHEMBL7855558 | 0.72 | KMT2A (0.53) | PTPN1KMT2ANOD1POLBCASP6 | |
| SCHEMBL7849798 | 0.72 | KMT2A (0.38) | KMT2ANOD1POLB | |
| SCHEMBL7854135 | 0.71 | PTPN1 (0.58) | RAB7APTPN1FABP4FABP5KMT2A | |
| SCHEMBL7033018 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404682-A1 | METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | Novo Nordisk A/S (DK) | 2004-04-07 | — | — | EP | claimed |
| WO-2003002569-A1 | METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2003-01-09 | — | — | WO | claimed |