Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034027 | 1.00 | RARB (0.40) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL27612883 | 0.86 | RARB (0.42) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL7033287 | 0.83 | HDAC4 (0.36) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL7033286 | 0.83 | HDAC4 (0.36) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL6869730 | 0.79 | ADRB2 (0.43) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL6869726 | 0.79 | ADRB2 (0.43) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL6877431 | 0.79 | ADRB2 (0.43) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL16562717 | 0.75 | RARB (0.46) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL12970138 | 0.75 | RAB9A (0.46) | RARBRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL7231979 | 0.74 | RARB (0.51) | RARBRAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |