Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | BRS3 | P32247 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7198194 | 0.96 | HSD11B1 (0.40) | HSD11B1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7201117 | 0.95 | HSD11B1 (0.40) | HSD11B1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7031378 | 0.94 | HSD11B1 (0.37) | HSD11B1BRS3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7037707 | 0.93 | HSD11B1 (0.36) | HSD11B1BRS3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7036446 | 0.93 | S1PR1 (0.32) | HSD11B1RAB9ANPC1MAPTNISCH | |
| SCHEMBL7031849 | 0.91 | HSD11B1 (0.37) | HSD11B1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7037024 | 0.90 | HSD11B1 (0.34) | HSD11B1BRS3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7033012 | 0.90 | EDNRB (0.32) | HSD11B1BRS3PSMB5TLR8 | |
| SCHEMBL7038530 | 0.89 | EDNRB (0.35) | — | |
| SCHEMBL7031629 | 0.89 | BRS3 (0.36) | HSD11B1BRS3RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620953-B1 | Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts | BASSELL POLYOLEFINE GMBH (DE) | 2003-09-16 | — | — | US | disclosed |
| EP-1133504-B1 | METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES | BASELL POLYOLEFINE GMBH (DE) | 2003-03-12 | — | — | EP | disclosed |