Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036446 | 0.91 | S1PR1 (0.32) | — | |
| SCHEMBL7036530 | 0.91 | EDNRB (0.33) | EDNRBEDNRAPTAFR | |
| SCHEMBL7034550 | 0.89 | SYK (0.33) | — | |
| SCHEMBL5836913 | 0.89 | ADRB2 (0.33) | — | |
| SCHEMBL7033012 | 0.89 | EDNRB (0.32) | EDNRBEDNRA | |
| SCHEMBL7034874 | 0.89 | HSD11B1 (0.39) | — | |
| SCHEMBL7193885 | 0.89 | S1PR1 (0.33) | EDNRBEDNRA | |
| SCHEMBL7198194 | 0.87 | HSD11B1 (0.40) | — | |
| SCHEMBL7201117 | 0.86 | HSD11B1 (0.40) | EGFR | |
| SCHEMBL7037129 | 0.86 | EDNRB (0.35) | EDNRBEDNRAPTAFRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620953-B1 | Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts | BASSELL POLYOLEFINE GMBH (DE) | 2003-09-16 | — | — | US | disclosed |
| EP-1133504-B1 | METHOD FOR PRODUCING MONOARYLOXY-ANSA-METALLOCENES | BASELL POLYOLEFINE GMBH (DE) | 2003-03-12 | — | — | EP | disclosed |