Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 14/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286806 | 0.86 | LMNA (0.55) | LMNATSHRMAPK1SCN4ASCN5A | |
| Hydrochloric Acid SCHEMBL28145471 | 0.85 | LMNA (0.53) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3241414 | 0.85 | P2RX4 (0.42) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL9420574 | 0.84 | LMNA (0.45) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL29376182 | 0.81 | P2RX4 (0.44) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3375661 | 0.81 | P2RX4 (0.44) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1477941 | 0.79 | NOTUM (0.46) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL8705933 | 0.77 | P2RX4 (0.57) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL28115945 | 0.75 | LMNA (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL27785934 | 0.75 | P2RX4 (0.58) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250334-B1 | Medicaments useful for the treatment of proliferative diseases | LILLY CO ELI (US) | 2004-05-19 | — | — | EP | disclosed |