Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040750 | 0.85 | GRIN2B (0.53) | GRIN2BCCR3MEN1KMT2A | |
| SCHEMBL7040756 | 0.84 | HTR1D (0.62) | CCR3 | |
| SCHEMBL7107899 | 0.83 | HTR1D (0.54) | CCR3 | |
| SCHEMBL7041705 | 0.77 | HTR1D (0.77) | — | |
| SCHEMBL7041675 | 0.77 | HTR1D (0.69) | — | |
| SCHEMBL9035485 | 0.77 | HTR1D (0.74) | — | |
| SCHEMBL9202889 | 0.73 | HTR1A (0.57) | KMT2ASMN1; SMN2 | |
| SCHEMBL240629 | 0.73 | OPRL1 (0.73) | CCR3MEN1KMT2ADRD4 | |
| SCHEMBL1575581 | 0.72 | SMN1; SMN2 (0.80) | GRIN2BCCR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8178651 | 0.71 | GRIN2B (0.57) | GRIN2BCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | claimed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | claimed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | claimed |
| EP-1037637-B1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | UNIV PRINCETON (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1037637-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029323-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5478828-A | Anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |