Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89524 | 0.72 | — | — | |
| SCHEMBL10054021 | 0.60 | MAOB (0.47) | ALDH1A1GAAKMT2AMAOB | |
| SCHEMBL7303185 | 0.60 | ALDH1A1 (0.49) | ALDH1A1GAAMAPTKMT2ACYP1A2 | |
| SCHEMBL28525073 | 0.59 | MAOB (0.40) | ALDH1A1MAPTKMT2AMAOBNPSR1 | |
| SCHEMBL20749318 | 0.58 | ALDH1A1 (0.47) | ALDH1A1MAPTKMT2ANPC1MAOB | |
| SCHEMBL9370171 | 0.58 | CYP2A6 (0.50) | KMT2A | |
| SCHEMBL20279531 | 0.56 | AXL (0.67) | ALDH1A1GAAMAPTPDE3BPDE3A | |
| SCHEMBL13817385 | 0.55 | USP2 (0.42) | ALDH1A1GAABRD4CREBBPNPC1 | |
| SCHEMBL9373771 | 0.55 | SIRT2 (0.43) | MAPTRAB9AKMT2AMAOBCYP2C19 | |
| SCHEMBL138271 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |