Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.71 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409737 | 0.88 | BAZ2B (0.57) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL4544324 | 0.88 | BAZ2B (0.67) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL1664710 | 0.88 | BAZ2B (0.67) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL2661552 | 0.87 | ALDH1A1 (0.69) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL9918754 | 0.86 | BAZ2B (0.65) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL26015021 | 0.86 | BAZ2B (0.69) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL16622895 | 0.86 | BAZ2B (0.64) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL9197119 | 0.85 | BAZ2B (0.63) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL11898897 | 0.85 | BAZ2B (0.63) | BAZ2BBAZ2AALDH1A1LMNAGAA | |
| SCHEMBL25815377 | 0.83 | BAZ2B (1.00) | BAZ2BBAZ2AALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109627235-A | A kind of high-energy insensitive energy-containing compound and its synthetic method | 南京理工大学 | 2019-04-16 | — | — | CN | claimed |
| US-20250221998-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-07-10 | — | — | US | disclosed |
| EP-4504730-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | Dana-Farber Cancer Institute, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| CN-119365454-A | Discovery of covalent EGFR inhibitors through cysteine 775 | 丹娜-法伯癌症研究院 | 2025-01-24 | — | — | CN | disclosed |
| CN-117126164-B | Pyrrolotriazines compound, preparation method and application thereof | 山东轩硕医药科技有限公司 | 2024-09-27 | — | — | CN | disclosed |
| US-20240228500-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. | 2024-07-11 | — | — | US | disclosed |
| US-20240228500-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. | 2024-07-11 | — | — | US | disclosed |
| US-12029791-B2 | Therapeutic conjugates | TOTUS MEDICINES INC. (US) | 2024-07-09 | — | — | US | disclosed |
| CN-117126164-A | Pyrrolotriazines compound, preparation method and application thereof | 山东轩硕医药科技有限公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2023196409-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-12 | — | — | WO | disclosed |
| US-9127015-B2 | Tricyclopyrazole derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-09-08 | — | — | US | disclosed |
| US-20120277214-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-11-01 | — | — | US | disclosed |
| EP-2479203-A1 | AROMATIC POLYESTER | Muroran Institute of Technology (JP) | 2012-07-25 | — | — | EP | disclosed |
| US-20120172570-A1 | AROMATIC POLYESTER | NITTA CORPORATION | 2012-07-05 | — | — | US | disclosed |
| US-8129493-B2 | Aromatic polyester | MURORAN INSTITUTE OF TECHNOLOGY (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20110269740-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110224343-A1 | MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME | MURORAN INSTITUTE OF TECHNOLOGY (JP) | 2011-09-15 | — | — | US | disclosed |
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |
| US-20110092662-A1 | AROMATIC POLYESTER | NITTA CORPORATION (JP) | 2011-04-21 | — | — | US | disclosed |
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12029791-B2 | Therapeutic conjugates | CD47, CD44, EPCAM | BAZ2B 935/4885BAZ2A 973/4885ALDH1A1 1307/4885 |
| US-20240228500-A1 | THERAPEUTIC CONJUGATES | CD47, CD44, EPCAM | BAZ2B 935/4885BAZ2A 973/4885ALDH1A1 1307/4885 |
| US-20110269740-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | BAZ2B 491/4885BAZ2A 336/4885ALDH1A1 4263/4885 |
| US-20110224343-A1 | MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME | F12, PHAX, WDR82 | BAZ2B 344/4885BAZ2A 674/4885ALDH1A1 1882/4885 |
| US-20120277214-A1 | TRICYCLOPYRAZOLE DERIVATIVES | CDK3, MAP3K15, CDK6 | BAZ2B 1997/4885BAZ2A 1970/4885ALDH1A1 3563/4885 |
| US-20250221998-A1 | DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775 | EGFR, ERBB2, ERBB3 | BAZ2B 313/4885BAZ2A 306/4885ALDH1A1 2954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.