Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28254287 | 0.89 | PDE10A (0.57) | PTGS2PTGS1PDE10AMMP2MMP9 | |
| Indoxole SCHEMBL29519430 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| Indoxole SCHEMBL42592 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL7039033 | 0.82 | ESR1 (0.67) | PTGS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28253409 | 0.80 | TUBB4A (0.48) | PTGS2PTGS1PDE10AMMP2MMP9 | |
| SCHEMBL7039067 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL7042910 | 0.80 | PTGS2 (0.72) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL18160179 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL7039642 | 0.76 | ESR2 (0.77) | PTGS2PTGS1TUBB4ATUBBTUBA3C | |
| SCHEMBL27566954 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | CHESWORTH RICHARD (US) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | ESR1, GPER1, ESR2 | PTGS2 735/4885PTGS1 617/4885PDE10A 1651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.