Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 16/20 | 0.42 |
| ▸ | AXL | P30530 | 14/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409298 | 1.00 | MERTK (0.42) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL2401521 | 0.91 | GPR119 (0.48) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL6411128 | 0.89 | MERTK (0.44) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL2402565 | 0.82 | MERTK (0.42) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL2400801 | 0.82 | MERTK (0.47) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL2401835 | 0.82 | MERTK (0.42) | MERTKAXLMETTYRO3P2RX7 | |
| Hydrochloric Acid SCHEMBL2402509 | 0.81 | MERTK (0.46) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL6415824 | 0.81 | LMNA (0.43) | — | |
| SCHEMBL2401891 | 0.80 | MEN1 (0.42) | MERTKAXLMETTYRO3P2RX7 | |
| SCHEMBL2403325 | 0.79 | KCNA5 (0.51) | MERTKAXLMETTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003000699-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2003-01-03 | — | — | WO | disclosed |