Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924453 | 1.00 | MAPK1 (0.50) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| SCHEMBL703571 | 1.00 | MAPK1 (0.50) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| SCHEMBL2087274 | 1.00 | MAPK1 (0.50) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| SCHEMBL29992606 | 1.00 | MAPK1 (0.50) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| Hydrochloric Acid SCHEMBL703781 | 0.97 | MAPK1 (0.48) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| Hydrochloric Acid SCHEMBL1005613 | 0.97 | MAPK1 (0.48) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| Hydrochloric Acid SCHEMBL1005612 | 0.97 | MAPK1 (0.48) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| Hydrochloric Acid SCHEMBL1005652 | 0.97 | MAPK1 (0.48) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| Hydrochloric Acid SCHEMBL703780 | 0.97 | MAPK1 (0.48) | MAPK1LMNACYP2C9CHRM4CHRM2 | |
| SCHEMBL334182 | 0.89 | CYP2C9 (0.55) | MAPK1LMNACYP2C9CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654620-B | Novel pyrazolopyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2023-08-04 | — | — | CN | claimed |
| EP-3847173-B1 | NOVEL PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-04-12 | — | — | EP | claimed |
| US-20210355122-A1 | PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2021-11-18 | — | — | US | claimed |
| EP-3847173-A1 | NOVEL PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-07-14 | — | — | EP | claimed |
| CN-112654620-A | Novel pyrazolopyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2021-04-13 | — | — | CN | claimed |
| EP-1484321-B1 | Process for preparing 1-methylindazole-3-carboxylic acid | CHEMAGIS LTD (IL) | 2011-04-06 | — | — | EP | claimed |
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | claimed |
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | claimed |
| EP-1742944-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2007-01-17 | — | — | EP | claimed |
| US-7060841-B2 | Process for preparing 1-methylindazole-3-carboxylic acid | CHEMAGIS LTD. (IL) | 2006-06-13 | — | — | US | claimed |
| WO-2006001894-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICAL CORPORATION (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION | 2005-11-10 | — | — | US | claimed |
| US-20040248960-A1 | Process for preparing 1-methylindazole-3-carboxylic acid | CHEMAGIS LTD. (IL) | 2004-12-09 | — | — | US | claimed |
| EP-1484321-A1 | Process for preparing 1-methylindazole-3-carboxylic acid | Chemagis Ltd. (IL) | 2004-12-08 | — | — | EP | claimed |
| EP-0419397-B1 | Substituted urea compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-06-08 | — | — | EP | claimed |
| EP-0220339-B1 | AZABICYCLOALKYL DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-11-08 | — | — | EP | claimed |
| US-4705858-A | ANTIEMETICS, DOPAMINE ANTAGONIST | BEECHAM GROUP P.L.C. (GB) | 1987-11-10 | — | — | US | claimed |
| EP-0220339-A1 | Azabicycloalkyl derivatives | BEECHAM GROUP PLC (GB) | 1987-05-06 | — | — | EP | claimed |
| JP-5070456-A | — | — | None | — | — | JP | disclosed |
| EP-0013138-A1 | Azabicycloalkyl derivatives, a process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1980-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355122-A1 | PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | KCNJ1, KCNJ11, SSB | MAPK1 616/4885LMNA 4444/4885CYP2C9 907/4885 |
| US-20040248960-A1 | Process for preparing 1-methylindazole-3-carboxylic acid | CYP3A43, CMA1, CYP3A7 | MAPK1 1554/4885LMNA 4118/4885CYP2C9 20/4885 |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | CHRNA7, CHRNA5, CHRNA2 | MAPK1 2332/4885LMNA 2361/4885CYP2C9 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.