Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | STS | P08842 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652849 | 0.94 | HTT (0.57) | HTTSMN1; SMN2NPSR1STSALDH1A1 | |
| SCHEMBL1276278 | 0.91 | HTT (0.48) | HTTSMN1; SMN2NPSR1STSALDH1A1 | |
| SCHEMBL652820 | 0.88 | HTT (0.53) | HTTSMN1; SMN2NPSR1STSALDH1A1 | |
| SCHEMBL651891 | 0.88 | HTT (0.53) | HTTSMN1; SMN2NPSR1STSALDH1A1 | |
| SCHEMBL2793493 | 0.84 | GPR119 (0.57) | HTTSMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL4139902 | 0.83 | DNMT3A (0.56) | HTTALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL5013239 | 0.83 | ALDH1A1 (0.51) | HTTSMN1; SMN2STSALDH1A1NPC1 | |
| SCHEMBL616004 | 0.83 | STS (0.60) | HTTSMN1; SMN2STSALDH1A1NPC1 | |
| SCHEMBL7381166 | 0.82 | ALDH1A1 (0.69) | HTTSMN1; SMN2STSALDH1A1MAPT | |
| SCHEMBL13434283 | 0.81 | HTT (0.51) | HTTSMN1; SMN2NPSR1STSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448566-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045942-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-06-05 | — | — | WO | disclosed |