Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15355913 | 0.78 | MAPT (0.44) | LMNAHTTMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9292846 | 0.75 | TSHR (0.41) | LMNAHTTMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL10848653 | 0.74 | HTT (0.38) | LMNAHTTMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL6978430 | 0.72 | LMNA (0.52) | LMNAHTTL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7057840 | 0.72 | LMNA (0.50) | LMNAMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6448611 | 0.71 | — | — | |
| SCHEMBL17563729 | 0.66 | CXCR4 (0.36) | SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL9066979 | 0.65 | LMNA (0.45) | LMNAHTTL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27747517 | 0.65 | LMNA (0.40) | LMNAHTTMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL8754688 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774133-B2 | Substituted spiroheterocyclic 1H-3-aryl-pyrrolidine-2,4-dione derivatives, processes for their preparation, and their use as pesticides | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-10 | — | — | US | disclosed |