Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.58 |
| ▸ | PDE1A | P54750 | 2/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.58 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.58 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039453 | 0.77 | PDE9A (0.61) | PDE9APDE1APDE1BPDE1CTRPC5 | |
| SCHEMBL7039414 | 0.76 | PDE9A (0.59) | PDE9APDE1APDE1BPDE1CTRPC5 | |
| SCHEMBL3492432 | 0.75 | PDE9A (0.73) | PDE9APDE1APDE1BPDE1CTRPC5 | |
| SCHEMBL6418301 | 0.73 | PDE9A (0.64) | PDE9APDE1APDE1BPDE1CPOLB | |
| SCHEMBL3492777 | 0.73 | PDE9A (0.54) | PDE9APDE1APDE1BPDE1CPOLB | |
| SCHEMBL3492585 | 0.73 | PDE1A (0.56) | PDE9APDE1APDE1BPDE1CTRPC5 | |
| SCHEMBL966361 | 0.69 | PDE5A (0.51) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL966971 | 0.68 | PDE9A (0.52) | PDE9APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL28528348 | 0.68 | KDM4E (0.42) | KDM4ELMNAMAPTKMT2AHDAC6 | |
| SCHEMBL18742150 | 0.68 | TNKS2 (0.50) | KDM4EADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PFIZER INC. | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PDE9A, PDE2A, PDE3A | PDE9A 1/4885PDE1A 62/4885PDE1B 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.