Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.59 |
| ▸ | PDE1A | P54750 | 3/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492777 | 0.90 | PDE9A (0.54) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL7039453 | 0.85 | PDE9A (0.61) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL3492432 | 0.82 | PDE9A (0.73) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL6418301 | 0.81 | PDE9A (0.64) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL3492585 | 0.80 | PDE1A (0.56) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL6371987 | 0.78 | PDE9A (0.40) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL3493363 | 0.77 | PDE9A (0.55) | PDE9APDE1APDE1BPDE1CPOLB | |
| SCHEMBL6366070 | 0.76 | PDE9A (0.44) | PDE9APDE1APDE1BPDE1CPDE5A | |
| SCHEMBL7036566 | 0.76 | PDE9A (0.58) | PDE9APDE1APDE1BPDE1CNPSR1 | |
| SCHEMBL3494974 | 0.76 | AR (0.41) | PDE9APDE1APDE1BPDE1CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PFIZER INC. | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PDE9A, PDE2A, PDE3A | PDE9A 1/4885PDE1A 62/4885PDE1B 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.