Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7036137 | 0.99 | LSS (0.44) | LSSGPR119GAASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7040589 | 0.88 | GAA (0.53) | GPR119GAAALDH1A1MAPK1NPC1 | |
| SCHEMBL7039131 | 0.83 | LSS (0.47) | LSSGAAFAAH | |
| Hydrochloric Acid SCHEMBL7040587 | 0.83 | LSS (0.52) | LSSALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL7042095 | 0.82 | LSS (0.46) | LSSGAAFAAH | |
| SCHEMBL7036643 | 0.81 | RAB9A (0.46) | GAASMN1; SMN2ALDH1A1MAPTTRPA1 | |
| Hydrochloric Acid SCHEMBL7040296 | 0.78 | LSS (0.41) | LSSSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7037887 | 0.77 | SMN1; SMN2 (0.56) | GPR119SMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7040948 | 0.76 | SMN1; SMN2 (0.55) | GPR119SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL2797073 | 0.75 | STS (0.57) | GPR119ALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060162-B1 | URETHANES DERIVED FROM AZACYCLOALKANES, THIO AND DITHIO ANALOGUES, PRODUCTION AND USE THEREOF AS 2,3 EPOXYSQUALENE LANESTEROL CYCLASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-03-19 | — | — | EP | claimed |
| US-6339096-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERLIPIDAEMIAS, HYPERCHOLESTEROLAEMIAS AND ATHEROSCLEROSIS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-01-15 | — | — | US | claimed |
| US-6339096-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERLIPIDAEMIAS, HYPERCHOLESTEROLAEMIAS AND ATHEROSCLEROSIS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-01-15 | — | — | US | disclosed |