Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035765 | 0.89 | GABRA1 (0.51) | PDE4BADORA2AADORA2BADORA1GABRA1 | |
| SCHEMBL15317761 | 0.85 | GABRA1 (0.47) | PDE4BADORA2AADORA2BADORA1GABRA1 | |
| SCHEMBL4054250 | 0.82 | KDM4E (0.55) | PDE4BHTTMETKDM4EPDE4A | |
| SCHEMBL8866625 | 0.82 | GABRA1 (0.47) | PDE4BADORA2AADORA2BADORA1GABRA1 | |
| SCHEMBL10194702 | 0.81 | KDM4E (0.52) | GABRA1GABRB2HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL4054492 | 0.81 | HTT (0.62) | HTTSMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL2823853 | 0.80 | MEN1 (0.53) | PDE4BHTTMETSMN1; SMN2PDE4A | |
| Bromide SCHEMBL5751833 | 0.80 | HTT (0.61) | HTTSMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL7037096 | 0.79 | KDM4E (0.51) | PDE4BHTTMETSMN1; SMN2HSD17B10 | |
| SCHEMBL14494768 | 0.78 | MET (0.50) | PDE4BMETSMN1; SMN2PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |
| EP-0835865-B1 | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides | DOW AGROSCIENCES LLC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6121251-A | CONTROLLING PHYTOPATHOGENIC FUNGI, INSECTS | ROHM AND HAAS COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0835865-A1 | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides | ROHM AND HAAS COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |