Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20656178 | 0.78 | PDCD1 (0.40) | PDCD1CD274IKBKBCHUKBAZ2B | |
| SCHEMBL24801870 | 0.75 | PDCD1 (0.46) | PDCD1CD274IKBKBCHUKBAZ2B | |
| SCHEMBL477484 | 0.72 | CYP2A6 (0.53) | IKBKB | |
| SCHEMBL5723315 | 0.72 | PDCD1 (0.43) | PDCD1CD274IKBKBCHUKBAZ2B | |
| SCHEMBL3858794 | 0.71 | PDCD1 (0.53) | PDCD1CD274BAZ2BBAZ2ABRD4 | |
| SCHEMBL20656011 | 0.70 | GPR35 (0.38) | PDCD1CD274IKBKBCHUKBAZ2B | |
| SCHEMBL1221964 | 0.70 | PDCD1 (0.54) | PDCD1CD274BAZ2BBAZ2ABRD4 | |
| SCHEMBL25094675 | 0.69 | PDCD1 (0.40) | PDCD1CD274BAZ2BBAZ2ABRD4 | |
| SCHEMBL25078757 | 0.69 | HIF1A (0.45) | PDCD1CD274BAZ2BBAZ2ABRD4 | |
| SCHEMBL18719400 | 0.68 | ESR2 (0.40) | TP53GAAMAPTALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030055058-A1 | Combination of a PTPase inhibitor and an ACE inhibitor | WYETH | 2003-03-20 | — | — | US | disclosed |
| US-20020198203-A1 | Combination of a PTPase inhibitor and a thiazolidinedione agent | WYETH (US) | 2002-12-26 | — | — | US | disclosed |
| WO-2002100396-A1 | COMBINATION OF A PTPase INHIBITOR AND A THIAZOLIDINEDIONE AGENT | WYETH (US) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002100398-A1 | COMBINATION OF A PTPASE INHIBITOR AND AN ACE INHIBITOR | WYETH (US) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002100397-A1 | COMBINATION OF A PTPase INHIBITOR AND AN ANTILIPEMIC AGENT | WYETH (US) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002098407-A1 | COMBINATION OF A PTPase INHIBITOR AND AN ALPHA-GLUCOSIDASE INHIBITOR | WYETH (US) | 2002-12-12 | — | — | WO | disclosed |
| WO-2002098410-A1 | COMBINATION OF A PTPASE INHIBITOR AND A SULFONYLUREA AGENT | WYETH (US) | 2002-12-12 | — | — | WO | disclosed |
| WO-2002098409-A1 | COMBINATION THERAPY FOR TYPE II DIABETES OR SYNDROME X | WYETH (US) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055058-A1 | Combination of a PTPase inhibitor and an ACE inhibitor | PTPN1, PTPN5, PTPN6 | PDCD1 1365/4885CD274 2370/4885IKBKB 1068/4885 |
| US-20020198203-A1 | Combination of a PTPase inhibitor and a thiazolidinedione agent | PTPRZ1, PTPRM, PTPRS | PDCD1 2613/4885CD274 3577/4885IKBKB 2390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.