Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20656011 | 0.86 | GPR35 (0.38) | PDCD1CD274CYP2A6APOBEC3GBAZ2B | |
| SCHEMBL477484 | 0.85 | CYP2A6 (0.53) | CYP2A6IKBKB | |
| SCHEMBL7037023 | 0.78 | PDCD1 (0.43) | PDCD1CD274APOBEC3GBAZ2BBAZ2A | |
| SCHEMBL1221964 | 0.75 | PDCD1 (0.54) | PDCD1CD274CYP2A6APOBEC3GBAZ2B | |
| SCHEMBL24801870 | 0.73 | PDCD1 (0.46) | PDCD1CD274BAZ2BBAZ2ABRD4 | |
| SCHEMBL477614 | 0.72 | LTA4H (0.61) | PDCD1CD274CYP2A6APOBEC3GBAZ2B | |
| SCHEMBL25094675 | 0.71 | PDCD1 (0.40) | PDCD1CD274APOBEC3GBAZ2BBAZ2A | |
| SCHEMBL5723315 | 0.71 | PDCD1 (0.43) | PDCD1CD274CYP2A6BAZ2BBAZ2A | |
| SCHEMBL25078757 | 0.71 | HIF1A (0.45) | PDCD1CD274CYP2A6BAZ2BBAZ2A | |
| SCHEMBL4873098 | 0.71 | ALDH1A1 (0.41) | PDCD1CD274APOBEC3GHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165266-A1 | RING CLOSURE REACTION | FLEXENABLE LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
| WO-2019011826-A1 | RING CLOSURE REACTION | MERCK PATENT GMBH (DE) | 2019-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165266-A1 | RING CLOSURE REACTION | LIG4, ATG7, RNF4 | PDCD1 1599/4885CD274 2198/4885CYP2A6 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.