Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040419 | 0.89 | PTGS2 (0.52) | ESR1ESR2PTGS2KDM4EALDH1A1 | |
| SCHEMBL15563263 | 0.83 | PTGS2 (0.72) | ESR1ESR2PTGS2MEN1KMT2A | |
| SCHEMBL7036763 | 0.81 | ESR1 (0.63) | ESR1ESR2PTGS2ALOX5KDM4E | |
| SCHEMBL7040768 | 0.80 | PTGS2 (0.54) | ESR1ESR2PTGS2MEN1KMT2A | |
| SCHEMBL27048273 | 0.79 | CHEK1 (0.49) | ESR1ESR2GSK3BCDK5CDK5R1 | |
| SCHEMBL7037980 | 0.78 | ESR1 (1.00) | ESR1ESR2PTGS2 | |
| SCHEMBL7041577 | 0.77 | ESR1 (0.73) | ESR1ESR2PTGS2MEN1KMT2A | |
| SCHEMBL7042896 | 0.76 | ESR1 (0.71) | ESR1ESR2PTGS2MEN1KMT2A | |
| SCHEMBL22310441 | 0.75 | PTGS2 (0.59) | ESR1ESR2PTGS2ALOX5MEN1 | |
| SCHEMBL31060913 | 0.75 | ESR1 (1.00) | ESR1ESR2PTGS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | CHESWORTH RICHARD (US) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220377-A1 | Indole compounds and their use as estrogen agonists/antagonists | ESR1, GPER1, ESR2 | ESR1 1/4885ESR2 3/4885PTGS2 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.