Citric Acid

Citric Acid

SCHEMBL7039340

CCN.Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.42
ALDH1A1 P00352 2/20 0.71
KDM4E B2RXH2 4/20 0.48
LMNA P02545 2/20 0.45
TSHR P16473 2/20 0.45
MAPT P10636 2/20 0.45
ALOX15 P16050 1/20 0.45
HMGCR P04035 1/20 0.44
CHRM1 P11229 1/20 0.44
TBXA2R P21731 1/20 0.44
ADRA1A P35348 1/20 0.44
CYP2D6 P10635 2/20 0.42
CYP1A2 P05177 1/20 0.42
KMT2A Q03164 1/20 0.42
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
SLC13A5 Q86YT5 3/20 0.40
ACLY P53396 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL7039332 1.00 ALDH1A1 (0.71) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL5875221 0.98 ALDH1A1 (0.75) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL5875233 0.98 ALDH1A1 (0.75) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL21145181 0.88 ALDH1A1 (0.68) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL5532762 0.88 ALDH1A1 (0.68) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL5874391 0.87 ALDH1A1 (0.83) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL31272367 0.87 ALDH1A1 (0.83) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL3454436 0.87 ALDH1A1 (0.83) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL6716639 0.87 ALDH1A1 (0.94) ALDH1A1KDM4ELMNATSHRMAPT
Citric Acid SCHEMBL5011203 0.87 ALDH1A1 (0.94) ALDH1A1KDM4ELMNATSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1454252-A Detergent compositions comprising a maltogenic alpha-amylase enzyme PROCTER & GAMBLE (US) 2003-11-05 CN disclosed
EP-1294845-A1 DETERGENT COMPOSITIONS COMPRISING A MALTOGENIC ALPHA-AMYLASE ENZYME The Procter & Gamble Company (US) 2003-03-26 EP disclosed
EP-1294844-A1 DETERGENT COMPOSITIONS COMPRISING A CYCLODEXTRIN GLUCANOTRANSFERASE ENZYME THE PROCTER & GAMBLE COMPANY (US) 2003-03-26 EP disclosed
EP-1224270-A1 MIMIC CELLULOSE BINDING DOMAIN THE PROCTER & GAMBLE COMPANY (US) 2002-07-24 EP disclosed
EP-1196531-A1 DETERGENT COMPOSITIONS COMPRISING A RETROGRADED STARCH DEGRADING ENZYME THE PROCTER & GAMBLE COMPANY (US) 2002-04-17 EP disclosed
EP-1196530-A1 DETERGENT COMPOSITIONS COMPRISING A RAW STARCH DEGRADING ENZYME THE PROCTER & GAMBLE COMPANY (US) 2002-04-17 EP disclosed
EP-1196529-A1 DETERGENT COMPOSITIONS COMPRISING AN AMYLOGLUCOSIDASE ENZYME THE PROCTER & GAMBLE COMPANY (US) 2002-04-17 EP disclosed
WO-2002002725-A1 DETERGENT COMPOSITIONS COMPRISING A CYCLODEXTRIN GLUCANOTRANSFERASE ENZYME THE PROCTER & GAMBLE COMPANY (US) 2002-01-10 WO disclosed
WO-2002002726-A1 DETERGENT COMPOSITIONS COMPRISING A MALTOGENIC ALPHA-AMYLASE ENZYME THE PROCTER & GAMBLE COMPANY (US) 2002-01-10 WO disclosed
CN-1329666-A laundry detergent and/or fabric care compositions PROCTER & GAMBLE (US) 2002-01-02 CN disclosed
WO-1998039402-A1 CLEANING COMPOSITIONS COMPRISING XYLAN DEGRADING ALKALINE ENZYME AND BLEACHING AGENT THE PROCTER & GAMBLE COMPANY (US) 1998-09-11 WO disclosed
WO-1998039403-A1 CLEANING COMPOSITIONS COMPRISING XYLAN DEGRADING ALKALINE ENZYME AND NON-PLANT CELL WALLS DEGRADING ENZYME THE PROCTER & GAMBLE COMPANY (US) 1998-09-11 WO disclosed
WO-1998039404-A1 DETERGENT COMPOSITIONS COMPRISING XYLAN DEGRADING ALKALINE ENZYME AND DYE TRANSFER INHIBITING POLYMERS THE PROCTER & GAMBLE COMPANY (US) 1998-09-11 WO disclosed
WO-1998028394-A1 DETERGENT COMPOSITIONS COMPRISING CHOLESTEROL ESTERASE THE PROCTER & GAMBLE COMPANY (US) 1998-07-02 WO disclosed
WO-1998007823-A1 DETERGENT COMPOSITIONS COMPRISING ANTIBODY CONTROLLED CELLULOLYTIC ACTIVITY THE PROCTER & GAMBLE COMPANY (US) 1998-02-26 WO disclosed
WO-1998007822-A1 DETERGENT COMPOSITIONS COMPRISING ANTIBODY CONTROLLED AMYLOLYTIC ACTIVITY THE PROCTER & GAMBLE COMPANY (US) 1998-02-26 WO disclosed
WO-1998007824-A1 DETERGENT COMPOSITIONS COMPRISING OXIDO-REDUCTASE ANTIBODY THE PROCTER & GAMBLE COMPANY (US) 1998-02-26 WO disclosed
WO-1998006810-A1 DETERGENT COMPOSITIONS COMPRISING ANTIBODY CONTROLLED LIPOLYTIC ACTIVITY THE PROCTER & GAMBLE COMPANY (US) 1998-02-19 WO disclosed
WO-1997043384-A1 DETERGENTS WITH PROTEASE ENZYME AND LACCASE ENZYME THE PROCTER & GAMBLE COMPANY (US) 1997-11-20 WO disclosed
WO-1997043385-A1 DETERGENT COMPOSITIONS COMPRISING A COMBINATION OF α-AMYLASES FOR MALODOR STRIPPING THE PROCTER & GAMBLE COMPANY (US) 1997-11-20 WO disclosed