Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.83 |
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 3/20 | 0.41 |
| ▸ | CPT2 | P23786 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5874391 | 1.00 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL30359537 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2396390 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL655551 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1243198 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1243199 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7155667 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6838001 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL15660063 | 0.92 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1332229 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108550700-B | Perovskite photosensitive layer, preparation method thereof and perovskite battery | 昆山协鑫光电材料有限公司 | 2022-02-22 | — | — | CN | claimed |
| CN-108550700-A | Perovskite photosensitive layer and preparation method thereof, perovskite battery | 苏州协鑫纳米科技有限公司 | 2018-09-18 | — | — | CN | claimed |
| CN-102149846-B | Methods and solutions for preventing the formation of metal particulate defect matter upon a substrate after a plating process | LAM RESERCH CORP | 2014-04-02 | — | — | CN | claimed |
| CN-102149846-A | Methods and solutions for preventing the formation of metal particulate defect matter upon a substrate after a plating process | LAM RES | 2011-08-10 | — | — | CN | claimed |
| WO-2010027950-A2 | METHODS AND SOLUTIONS FOR PREVENTING THE FORMATION OF METAL PARTICULATE DEFECT MATTER UPON A SUBSTRATE AFTER A PLATING PROCESS | LAM RESEARCH (US) | 2010-03-11 | — | — | WO | claimed |
| US-20100062164-A1 | Methods and Solutions for Preventing the Formation of Metal Particulate Defect Matter Upon a Substrate After a Plating Process | LAM RESEARCH (US) | 2010-03-11 | — | — | US | claimed |
| CN-108550700-B | Perovskite photosensitive layer, preparation method thereof and perovskite battery | 昆山协鑫光电材料有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-113853185-A | Implantable ocular drug delivery devices and methods | 迈克罗欧普提克斯股份有限公司 | 2021-12-28 | — | — | CN | disclosed |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| CN-110430875-A | Therapeutic agent for non-motor symptoms relevant to Parkinson's disease | SUMITOMO DAINIPPON PHARMA CO LTD | 2019-11-08 | — | — | CN | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| EP-3518878-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| US-5800833-A | LIPOSOMES | UNIVERSITY OF BRITISH COLUMBIA (CA) | 1998-09-01 | — | — | US | disclosed |
| US-5785987-A | PREPARING MIXTURE OF LIPOSOMES IN AQUEOUS SOLUTION, ESTABLISHING CONCENTRATION GRADIENT OF METHYLAMINE ACROSS MEMBRANE, INCUBATING WITH ZWITTERIONIC QUINOLONE ANTIBACTERIAL AGENT | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1998-07-28 | — | — | US | disclosed |
| CN-1171787-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1998-01-28 | — | — | CN | disclosed |
| EP-0812186-A1 | METHOD FOR LOADING LIPID VESICLES | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1997-12-17 | — | — | EP | disclosed |
| CN-1138332-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1996-12-18 | — | — | CN | disclosed |
| WO-1996026715-A1 | METHOD FOR LOADING LIPID VESICLES | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1996-09-06 | — | — | WO | disclosed |
| US-4169817-A | PROTEASE | MIDWEST BIOCHEMICAL CORPORATION (US) | 1979-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | MEN1 3369/4885ALDH1A1 1010/4885HMGCR 3426/4885 |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CD44, PCNA | MEN1 2001/4885ALDH1A1 1465/4885HMGCR 4250/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | MEN1 3038/4885ALDH1A1 1179/4885HMGCR 3266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.