Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16215837 | 0.86 | ALDH1A1 (0.50) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL13092658 | 0.79 | TSHR (0.45) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL15881333 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TSHRSMN1; SMN2NPSR1 | |
| SCHEMBL15882546 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TSHRSMN1; SMN2NPSR1 | |
| SCHEMBL21001393 | 0.77 | ALDH1A1 (0.38) | ALDH1A1HSD17B10SMN1; SMN2KMT2AMAPT | |
| SCHEMBL9864854 | 0.75 | CYP3A4 (0.42) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL9866637 | 0.75 | CYP3A4 (0.42) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| Diethylamine SCHEMBL27819675 | 0.75 | LMNA (0.40) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL3264903 | 0.72 | CYP3A4 (0.45) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 | |
| (Phenylsulfonyl)Benzene SCHEMBL10871438 | 0.72 | CYP3A4 (0.51) | CYP3A4ALDH1A1HSD17B10TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414450-A1 | (PYRIDINYL AND PYRIMIDYL)TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003007950-A1 | (PYRIDINYL AND PYRIMIDYL) TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-01-30 | — | — | WO | disclosed |