Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.32 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860347 | 0.80 | ALDH1A1 (0.38) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1MAPT | |
| SCHEMBL7041081 | 0.69 | MGLL (0.40) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1USP2 | |
| SCHEMBL14726017 | 0.69 | TDP1 (0.47) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL30396025 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1LMNA | |
| SCHEMBL5000976 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1LMNA | |
| SCHEMBL4199767 | 0.66 | CES1 (0.57) | ALDH1A1MAPTLMNAKDM4EL3MBTL1 | |
| SCHEMBL4415567 | 0.66 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1HTT | |
| SCHEMBL12043657 | 0.66 | TTR (0.52) | SMN1; SMN2ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL4415354 | 0.65 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1MAPT | |
| SCHEMBL7688831 | 0.65 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2D6CYP2C9ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833819-B1 | NOVEL N-(2-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0833819-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0833819-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5691332-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO., INC. (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1996040656-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |