Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28166572 | 0.79 | HRH1 (0.44) | SLC6A3SLC6A2 | |
| SCHEMBL8633394 | 0.79 | SMN1; SMN2 (0.48) | SLC6A3TSHRSLC6A2SMN1; SMN2 | |
| SCHEMBL25209792 | 0.72 | — | — | |
| SCHEMBL5129037 | 0.72 | — | — | |
| SCHEMBL2483568 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL8230082 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL12435784 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL16174384 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL16172571 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL12581063 | 0.71 | KDM4E (0.62) | ADRA2CKDM4EADRA2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676409-B1 | Erythromycin derivatives, their process for preparation and their application as medicaments | AVENTIS PHARMA SA (FR) | 2003-03-19 | — | — | EP | disclosed |
| WO-1995027720-A1 | NOVEL ERYTHROMYCIN DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS DRUGS | ROUSSEL UCLAF (FR) | 1995-10-19 | — | — | WO | disclosed |
| EP-0676409-A1 | Erythromycin derivatives, their process for preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1995-10-11 | — | — | EP | disclosed |