Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2421458 | 0.84 | TSHR (0.66) | SMN1; SMN2TSHRSLC6A3L3MBTL1SLC6A2 | |
| SCHEMBL28752724 | 0.81 | SLC6A3 (0.41) | SMN1; SMN2TSHRSLC6A3IDO1HPGD | |
| SCHEMBL14033955 | 0.81 | SLC6A3 (0.45) | TSHRSLC6A3IDO1TDO2HPGD | |
| SCHEMBL31040275 | 0.81 | TSHR (0.36) | SMN1; SMN2TSHRIDO1 | |
| SCHEMBL2974022 | 0.81 | SLC6A3 (0.45) | TSHRSLC6A3IDO1TDO2SLC6A2 | |
| SCHEMBL23931525 | 0.80 | IDO1 (0.43) | TSHRSLC6A3IDO1TDO2SLC6A2 | |
| SCHEMBL30011604 | 0.80 | IDO1 (0.43) | TSHRSLC6A3IDO1TDO2SLC6A2 | |
| SCHEMBL23931527 | 0.80 | IDO1 (0.43) | TSHRSLC6A3IDO1TDO2SLC6A2 | |
| SCHEMBL7039736 | 0.79 | ADRA2C (0.39) | SMN1; SMN2TSHRSLC6A3SLC6A2 | |
| SCHEMBL8746252 | 0.78 | CYP19A1 (0.44) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047169-C | (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives | ASTRA AB (SE) | 1999-12-08 | — | — | CN | claimed |
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | claimed |
| CN-1126991-A | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives | ASTRA AB (SE) | 1996-07-17 | — | — | CN | claimed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | claimed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | claimed |
| US-5712299-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | ASTRA AKTIEBOLAG (SE) | 1998-01-27 | — | — | US | disclosed |
| CN-1126991-A | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives | ASTRA AB (SE) | 1996-07-17 | — | — | CN | disclosed |
| EP-0707574-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001968-A1 | NOVEL (1-PHENYL-1-HETEROCYCLYL)METHANOL AND (1-PHENYL-1-HETEROCYCLYL)METHYLAMINE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |