Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 18/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340457 | 0.89 | ALDH1A1 (0.47) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL2768607 | 0.87 | TSHR (0.50) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL341775 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL339784 | 0.85 | LIPE (0.44) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL341667 | 0.85 | HCRTR1 (0.43) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL341485 | 0.85 | ALDH1A1 (0.43) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL2770608 | 0.84 | HTR2A (0.41) | HCRTR1HCRTR2HTR2C | |
| SCHEMBL341292 | 0.83 | LIPE (0.43) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL340226 | 0.82 | LIPE (0.40) | HCRTR1HCRTR2CYP3A4LIPE | |
| SCHEMBL2768134 | 0.81 | ALDH1A1 (0.47) | HCRTR1HCRTR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461339-A2 | SPIROAZACYCLIC COMPOUNDS AS MONOAMINE RECEPTOR MODULATORS | Acadia Pharmaceuticals Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003057698-A2 | SPIROAZACYCLIC COMPOUNDS AS MONOAMINE RECEPTOR MODULATORS | ACADIA PHARMACEUTICALS, INC. (US) | 2003-07-17 | — | — | WO | disclosed |