Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.76 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.76 |
| ▸ | THPO | P40225 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31318264 | 1.00 | MAPT (0.76) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1887588 | 1.00 | MAPT (0.76) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1887586 | 1.00 | MAPT (0.76) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL15486529 | 0.90 | MAPT (0.62) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28181870 | 0.88 | PTGS2 (0.58) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL11772474 | 0.88 | MAPT (0.59) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2336923 | 0.87 | PTGS1 (0.71) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13433693 | 0.87 | PTGS1 (0.71) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2336917 | 0.87 | PTGS1 (0.71) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 0.86 | PTGS1 (1.00) | MAPTPTGS1PTGS2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030049807-A1 | Micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | INSTITUTO BIOCHIMICO ITALIANO GIOVANNI LOREZINI S.P.A. (IT) | 2003-03-13 | — | — | US | claimed |
| EP-1291435-A2 | A micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 2003-03-12 | — | — | EP | claimed |
| EP-4272761-A2 | COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS | Medicon Pharmaceuticals, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |