Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040645 | 0.87 | KMT2A (0.36) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7040649 | 0.87 | KMT2A (0.36) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7194693 | 0.86 | PDE5A (0.41) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7194688 | 0.86 | PDE5A (0.41) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7109021 | 0.82 | PDE5A (0.36) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7151884 | 0.79 | PDE4B (0.39) | PDE5APDE4BPDE3A | |
| SCHEMBL7040393 | 0.77 | PDE5A (0.44) | MEN1KMT2AALDH1A1PDE5APDE4B | |
| SCHEMBL7038848 | 0.76 | PDE5A (0.43) | MEN1KMT2AALDH1A1PDE5APDE4B | |
| SCHEMBL7039977 | 0.75 | MAPT (0.38) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7039975 | 0.75 | MAPT (0.38) | MAPTNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003004494-A1 | PYRIDAZINONE COMPOUND AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-16 | — | — | WO | disclosed |