Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20436538 | 0.85 | CACNA1C (0.49) | KCNH2CACNA1CSCN5AAPPHSD11B1 | |
| SCHEMBL852472 | 0.81 | APP (0.53) | KCNH2SCN5AAPPHSD11B1NPSR1 | |
| SCHEMBL12895814 | 0.81 | CACNA1C (0.56) | KCNH2CACNA1CSCN5AAPPHSD11B1 | |
| SCHEMBL24618394 | 0.79 | KCNH2 (0.55) | KCNH2NPSR1 | |
| SCHEMBL13626475 | 0.79 | HSD11B1 (0.42) | KCNH2APPHSD11B1MAPK8NPSR1 | |
| SCHEMBL14518469 | 0.78 | SCN5A (0.66) | KCNH2CACNA1CSCN5AHSD11B1CNR1 | |
| SCHEMBL7796045 | 0.78 | CACNA1C (0.49) | KCNH2CACNA1CSCN5AAPPHSD11B1 | |
| SCHEMBL22490218 | 0.77 | APP (0.46) | KCNH2CACNA1CSCN5AAPPHSD11B1 | |
| SCHEMBL1040083 | 0.76 | KCNH2 (0.47) | KCNH2CACNA1CSCN5AAPPHSD11B1 | |
| SCHEMBL4273309 | 0.76 | KCNH2 (0.52) | KCNH2HSD11B1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977735-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6191304-B1 | REDUCTION OF AN ALKYL 3-ALKYLOXY-11-OXO-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-10-ACETATE BY HYDROGENOLYSIS USING A PALLADIUM/ACTIVATED CARBON CATALYST; INTERMEDIATES FOR3-((4-AMINOPYRID-2-YL)AMINOALKYLENEOXY) DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-02-20 | — | — | US | disclosed |
| US-6069158-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0977735-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-04-05 | — | — | EP | disclosed |
| CN-1249745-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2000-04-05 | — | — | CN | disclosed |
| EP-0977735-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998030542-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-16 | — | — | WO | disclosed |