Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20436545 | 0.85 | HSD11B1 (0.40) | HSD11B1APPNPSR1ATMPTGER2 | |
| SCHEMBL852472 | 0.81 | APP (0.53) | HSD11B1APPNPSR1NR3C2KCNH2 | |
| SCHEMBL12883344 | 0.79 | CHRNB2 (0.41) | HSD11B1KCNH2ATMNCF1 | |
| SCHEMBL7040754 | 0.79 | KCNH2 (0.46) | HSD11B1APPNPSR1NR3C2KCNH2 | |
| SCHEMBL18160808 | 0.78 | NCF1 (0.36) | APPNPSR1NR3C2KCNH2PDE10A | |
| SCHEMBL26441388 | 0.76 | NPSR1 (0.38) | APPNPSR1ATMNCF1IDH1 | |
| SCHEMBL4273309 | 0.76 | KCNH2 (0.52) | HSD11B1NPSR1KCNH2 | |
| SCHEMBL6320838 | 0.76 | NR3C2 (0.43) | HSD11B1NR3C2MAPK8 | |
| SCHEMBL6697790 | 0.75 | CCNT1 (0.42) | HSD11B1APPNR3C2PTGER2 | |
| SCHEMBL24848013 | 0.74 | HCRTR1 (0.39) | HSD11B1NPSR1KCNH2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142967-A1 | THERAPEUTIC PROSTAGLANDIN COMPOUNDS USED AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN, INC. (US) | 2009-11-26 | — | — | WO | disclosed |