Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.74 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 5/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.46 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7037399 | 1.00 | GSR (0.74) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine SCHEMBL3000505 | 0.94 | GSR (0.64) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine Aketoglutarate SCHEMBL3000503 | 0.94 | GSR (0.64) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7048440 | 0.87 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7048439 | 0.87 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine SCHEMBL6757036 | 0.87 | GSR (0.64) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL31541159 | 0.86 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28080783 | 0.86 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL18396696 | 0.86 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL18396695 | 0.86 | GSR (0.91) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1116727-B1 | PEPTIDE DERIVATIVE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-1116727-A1 | PEPTIDE DERIVATIVE | Takeda Chemical Industries, Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |