SCHEMBL7040931

SCHEMBL7040931

CCCc1c(OCCCSc2ccc(OC(=O)CC)cc2Cl)ccc2c(CC)nsc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.53
PPARG P37231 13/20 0.53
PPARD Q03181 11/20 0.53
NR1H2 P55055 2/20 0.45
NR1H3 Q13133 2/20 0.45
NPC1 O15118 1/20 0.36
LMNA P02545 1/20 0.36
PKM P14618 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
ACACB O00763 1/20 0.34
KDM4E B2RXH2 1/20 0.33
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8669133 0.93 PPARG (0.53) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7042415 0.85 PPARD (0.62) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7039665 0.84 PPARD (0.73) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7044865 0.83 PPARG (0.54) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7044053 0.82 PPARA (0.67) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7037984 0.79 PPARA (0.59) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL6934155 0.79 PPARG (0.65) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7046133 0.77 PPARA (0.74) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL6560623 0.76 PPARD (0.47) PPARAPPARGPPARDNR1H2NR1H3
SCHEMBL7043241 0.76 PPARG (0.74) PPARAPPARGPPARDNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882029-B1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO INC (US) 2003-04-02 EP claimed
US-6090836-A DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION MERCK & CO., INC. (US) 2000-07-18 US claimed
EP-0882029-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS Merck & Co., Inc. (US) 1998-12-09 EP claimed
WO-1997028137-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO., INC. (US) 1997-08-07 WO claimed
EP-0882029-B1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO INC (US) 2003-04-02 EP disclosed
US-6090836-A DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION MERCK & CO., INC. (US) 2000-07-18 US disclosed
EP-0882029-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS Merck & Co., Inc. (US) 1998-12-09 EP disclosed
WO-1997028137-A1 HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed