Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.53 |
| ▸ | PPARA | Q07869 | 10/20 | 0.53 |
| ▸ | PPARD | Q03181 | 9/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040931 | 0.93 | PPARA (0.53) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7039665 | 0.85 | PPARD (0.73) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7046133 | 0.84 | PPARA (0.74) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7044865 | 0.84 | PPARG (0.54) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7042415 | 0.84 | PPARD (0.62) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL6938537 | 0.76 | PPARG (0.49) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7044053 | 0.74 | PPARA (0.67) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL6932943 | 0.74 | PPARG (0.60) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL8442373 | 0.73 | PPARG (0.46) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL7037984 | 0.72 | PPARA (0.59) | PPARGPPARAPPARDNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |