Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036479 | 0.91 | ULK1 (0.45) | ULK1ENPP3ENPP1NPC1RAB9A | |
| SCHEMBL5036018 | 0.90 | SMN1; SMN2 (0.43) | ENPP3ENPP1NPC1RAB9AENPP2 | |
| SCHEMBL5037833 | 0.85 | ENPP1 (0.51) | ENPP3ENPP1NPC1RAB9AENPP2 | |
| SCHEMBL5033498 | 0.84 | ENPP3 (0.44) | ENPP3ENPP1ENPP2KMT2ASMN1; SMN2 | |
| SCHEMBL5036631 | 0.84 | KMT2A (0.45) | ENPP3ENPP1ENPP2KMT2ATUBB4A | |
| SCHEMBL5036147 | 0.83 | SMN1; SMN2 (0.42) | ULK1ENPP3ENPP1NPC1RAB9A | |
| SCHEMBL5043081 | 0.83 | SMN1; SMN2 (0.48) | ENPP3ENPP1NPC1RAB9AENPP2 | |
| SCHEMBL5040856 | 0.83 | TP53 (0.42) | ENPP3ENPP1NPC1RAB9AENPP2 | |
| SCHEMBL5040722 | 0.83 | SMN1; SMN2 (0.42) | ENPP3ENPP1NPC1RAB9AENPP2 | |
| SCHEMBL5036505 | 0.82 | SMN1; SMN2 (0.43) | ENPP3ENPP1NPC1RAB9AENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |