Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.57 |
| ▸ | HRH1 | P35367 | 9/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042319 | 0.95 | PARP1 (0.52) | PARP1HRH1PARP2JAK2JAK1 | |
| SCHEMBL7040941 | 0.92 | PARP1 (0.57) | PARP1HRH1PARP2JAK2JAK1 | |
| SCHEMBL7043338 | 0.92 | PARP1 (0.59) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7046731 | 0.91 | PARP1 (0.56) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7045127 | 0.91 | PARP1 (0.47) | PARP1HRH1DRD2 | |
| SCHEMBL7042613 | 0.90 | PARP1 (0.56) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7042083 | 0.90 | PARP1 (0.56) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7041972 | 0.90 | PARP1 (0.55) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7043782 | 0.88 | PARP1 (0.52) | PARP1HRH1PARP2DRD2BRD4 | |
| SCHEMBL7035297 | 0.87 | PARP1 (0.52) | PARP1HRH1PARP2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |