Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039722 | 0.96 | PARP1 (0.45) | PARP1PARP2HRH1THRBTERT | |
| SCHEMBL7042195 | 0.93 | PARP1 (0.42) | PARP1HRH1THRBDRD2 | |
| SCHEMBL7041579 | 0.90 | JAK2 (0.40) | PARP1BRD4CREBBPTHRBTERT | |
| SCHEMBL7046731 | 0.90 | PARP1 (0.56) | PARP1PARP2HRH1BRD4CREBBP | |
| SCHEMBL7042613 | 0.89 | PARP1 (0.56) | PARP1PARP2HRH1BRD4CREBBP | |
| SCHEMBL7041326 | 0.88 | PARP1 (0.43) | PARP1THRBTERTDRD2SMN1; SMN2 | |
| SCHEMBL7041918 | 0.88 | PARP1 (0.40) | PARP1PARP2THRBTERTSMN1; SMN2 | |
| SCHEMBL5619904 | 0.87 | PARP1 (0.67) | PARP1PARP2HRH1THRBTERT | |
| SCHEMBL7043890 | 0.87 | PARP1 (0.35) | PARP1HRH1THRBTERTSMN1; SMN2 | |
| SCHEMBL7046819 | 0.86 | CHRM1 (0.40) | PARP1PARP2HRH1TERTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |