Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043890 | 0.95 | PARP1 (0.35) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7046819 | 0.91 | CHRM1 (0.40) | PARP1CYP1A2CYP3A4CYP2D6TERT | |
| SCHEMBL7043346 | 0.90 | PARP1 (0.50) | PARP1TERTSMN1; SMN2THRBBRD4 | |
| SCHEMBL7041448 | 0.88 | TAAR1 (0.36) | PARP1CYP1A2CYP3A4CYP2D6TERT | |
| SCHEMBL7039722 | 0.88 | PARP1 (0.45) | PARP1CYP1A2CYP3A4CYP2D6TERT | |
| SCHEMBL5621352 | 0.87 | PARP1 (0.52) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7040063 | 0.87 | SMN1; SMN2 (0.36) | PARP1CYP1A2CYP3A4CYP2D6TERT | |
| SCHEMBL7042195 | 0.86 | PARP1 (0.42) | PARP1CYP2D6THRB | |
| SCHEMBL7040421 | 0.85 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL7041326 | 0.85 | PARP1 (0.43) | PARP1CYP1A2CYP3A4CYP2D6TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |