Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041043 | 0.89 | PDE4D (0.46) | MAPTTDP1PDE4DALDH1A1HPGD | |
| SCHEMBL7145674 | 0.87 | PDE10A (0.50) | PDE4DHPGDTSHRJAK1HSP90AB1 | |
| SCHEMBL7146570 | 0.86 | PDE4D (0.48) | MAPTPDE4DTSHRJAK1FYN | |
| SCHEMBL6876513 | 0.86 | PDE4D (0.48) | MAPTPDE4DJAK1FYNPDE10A | |
| SCHEMBL2250839 | 0.85 | PDE4D (0.64) | MAPTPDE4DKDM4EJAK1HSP90AB1 | |
| SCHEMBL7043078 | 0.84 | JAK1 (0.60) | MAPTTDP1PDE4DKDM4EALDH1A1 | |
| SCHEMBL7150018 | 0.83 | DYRK3 (0.47) | PDE4DKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7146861 | 0.82 | PDE4D (0.70) | PDE4DFYN | |
| SCHEMBL508900 | 0.81 | PDE4D (0.76) | PDE4D | |
| SCHEMBL3304801 | 0.80 | JAK1 (0.75) | MAPTTDP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | claimed |
| EP-1412352-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003010167-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-06 | — | — | WO | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |