Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145674 | 0.86 | PDE10A (0.50) | PDE4DPDE10AJAK1 | |
| SCHEMBL7043841 | 0.86 | MAPT (0.51) | PDE4DFYNPDE10AMAPTJAK1 | |
| SCHEMBL7146570 | 0.85 | PDE4D (0.48) | PDE4DFYNPDE10AMAPTJAK1 | |
| SCHEMBL7150018 | 0.84 | DYRK3 (0.47) | PDE4DFYNPDE10A | |
| SCHEMBL2257907 | 0.84 | MAPT (0.49) | PDE4DFYNPDE10AMAPTJAK1 | |
| SCHEMBL2250839 | 0.84 | PDE4D (0.64) | PDE4DPDE10AMAPTJAK1 | |
| SCHEMBL7146861 | 0.81 | PDE4D (0.70) | PDE4DFYN | |
| SCHEMBL510004 | 0.81 | PDE4D (0.74) | PDE4D | |
| SCHEMBL7041043 | 0.81 | PDE4D (0.46) | PDE4DFYNMAPTJAK1 | |
| SCHEMBL7144542 | 0.78 | PDE4D (0.53) | PDE4DFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | claimed |
| EP-1412352-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003010167-A1 | 8-METHOXY-(1,2,4)TRIAZOLO(1,5-A)PYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-06 | — | — | WO | disclosed |
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |